Top 3 Must Have Skill Sets:
spectroscopic techniques such as FTIR, CD, and NMR spectroscopy for protein structure analysis. (1+ years of experience) (biophysical for protein categorization)
Hand-on experience with HPLC systems for the separation and characterization of proteins. (1+ years of experience)
Laboratory experience (industrial/academia)
Experience with qPCR to characterize and quantify nucleic acids, and the application of immunoassays for the detection and quantification of antibodies. (impurities of antibodies)
Day to Day Responsibilities:
The successful candidate will perform sample preparation, testing, methods development and characterization using spectroscopic techniques such as Fourier Transform Infrared (FTIR) spectroscopy, Circular Dichroism (CD) spectroscopy, and Nuclear Magnetic Resonance (NMR) spectroscopy to support product and process characterization activities for protein biopharmaceutical products. The candidate should also have experience with high-performance liquid chromatography (HPLC) of proteins and using quantitative PCR (qPCR) and immunoassays. Activities will include the characterizing of higher order structure and aggregation attributes for biologicals, the characterization of nucleic acids and the quantification of antibodies, and will be applied in comparability and similarity studies, technology development efforts, and in non-routine investigations. Other duties include sample preparation, complex data analyses, generation of technical documents and technical presentations, and setting of acceptance criteria in support of process development, process/method transfers, and comparability/similarity studies. The position requires demonstrated ability to work collaboratively with other scientists, and to have the capacity to be flexible and adaptive to changing priorities.
M.S degree in Chemistry, Biochemistry, Biotechnology, Physics or related discipline, OR
B.S. degree in Chemistry, Biochemistry, Biotechnology, Chemical Engineering, Physics or related discipline with 3+ years work experience in the biopharmaceutical industry.
Two or more years of experience directly related to biophysical characterization in protein drug products, including the use of spectroscopic techniques such as FTIR, CD, and NMR spectroscopy for protein structure analysis.
Hand-on experience with HPLC systems for the separation and characterization of proteins.
Experience with qPCR to characterize and quantify nucleic acids, and the application of immunoassays for the detection and quantification of antibodies.
Strong laboratory analytical skills, including routine testing as well as the design and execution of scientific experiments and interpretation of results.
Experience developing, qualifying, and/or validating analytical methods, analyzing data, and setting acceptance criteria to support product comparability/similarity studies.
Demonstrated ability to work collaboratively with other scientists on multidisciplinary, cross-functional teams.
"This posting is for Contingent Worker, not an FTE"