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South San Francisco,, CA
Onsite - South San Francisco

Ideal Candidate: 
  • Bachelors cell or molecular biology. fresh graduate is fine, lab experience preferred. Summer internship experience preferred.
  • Cell bio major. start immediately

Top 3 Must Have Skill Sets:    
  • cell culture; cell-based assay; data analysis

Basic Minimum Qualifications:
  • 0+ Years w/ Relevant BS OR equivalent 2+ Years w/ Relevant AS OR equivalent 4+ Years w/ HS Foundational knowledge of technical principles, theories, and concepts to perform routine work in a role.

Day to Day Responsibilities:    
  • cell culture, cell-based assay execution, data analysis

Position responsibilities include:
  • The development and optimization of cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets
  • Design and execute laboratory experiments, generate and interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
  • Learn, apply, and incorporate automation solutions during assay development, assay troubleshooting, mechanism-of-action studies, data analysis, and reporting
  • Semi-independently plan and execute experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem-solving skills
  • Show excellent teamwork and communication skills as this role requires an ability to work closely with other scientists in the group and across.
  • Adherence to good laboratory conduct, documentation practices, and safety guidelines

Preferred Qualifications
  • Experience working as part of a multi-disciplinary team
  • Familiarity with assay technologies including luminescence, fluorescence and FRET/BRET with experience in the utilization of lab automation across assay development and screening
  • Ability to create and establish priorities, manage work plans, and meet timelines
  • A flexible mindset with strong interpersonal, communication and problem-solving skills
  • Demonstrated initiative, teamwork, collaboration and passion for developing technical expertise across assay development to routine execution
  • Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays and readouts (e.g., TR-FRET, BRET, PCA, AlphaLISA, MSD, HCS, luminescence and fluorescence-based reporter and/or label-free assays)
  • Broad experience and expertise in molecular reagent generation and cell line engineering using gene editing approaches (CRISPR) as well as development and implementation of novel cellular target engagement, activity, and PPI assays (e.g., immunoassays, second messenger generation, ion flux, reporter, protein stability, PPI (splitNanoLuc, splitβ-gal), gene activation, cellular imaging)
  • Experience with cell characterization and analytical techniques such as DNA sequencing, qPCR and protein expression as well as expertise with phenotypic and functional characterization of immortalized or primary cells
  • Experience with assay development in RNA therapeutics such as high-throughput RT-qPCR, RNA-FISH, and characterization of in-cell RNA binding
  • Established capabilities in setting-up and operation of multimode plate readers (e.g., FLIPR, EnVision, ViewLux, PHERAstar) and automated liquid handlers (e.g., Bravo, Echo, Tempest, BlueWasher) in the development of 384-well microtiter plate assays.

PAY RATE : $26/hr. on W2

"This posting is for Contingent Worker, not an FTE"

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